Target Discovery

In Target Discovery, the project team strives to improve a) Target Validation: Define and execute a set of experiments that establishes the target in relation to proposed therapeutic intervention; and b) Target Tractability: Express and purify the target protein; Ensure that suitable quantities can be obtained from a stable cell line for future assay work; Determine suitability of native protein for assay development; Identify tool agents to assist in assay development.

In companies that have the resources to develop either small molecule, peptide or protein-based drugs, the team may need to decided in this stage whether to pursue one strategy or both.  Should both strategies be desirable we recommend that the team may both strategies be pursued within one team and manage the differing processes in sub-team meetings.